Our goal is to explore and investigate mechanisms of environmental lung diseases (asthma, fibrosis, cancer) caused by agents such as metals, air pollution particles and fibers, and engineered nanoparticles. We also seek to identify physical and chemical properties of nanomaterials that trigger fibrotic, allergic, or carcinogenic reactions in the lung and other organ systems in order to provide information for the design of safer nanomaterials. Of particular interest is determining the pathogenic potential of nanomaterials in susceptible populations and individuals with pre-existing disease, especially asthma. Our research, funded by The National Insitute of Environmental Health Sciences (NIEHS) and The National Science Foundation (NSF), is integrated with national and international consortia of other scientists to collectively understand the health risks associated with emerging nanotechnology. Our goal is to conduct research at NC State University, as well as collaborating internationally, to provide fundamental information for the prevention of future disease that might occur from emerging nanotechnologies. We also hope to provide knowledge on mechanisms of fatal or debilitating environmental lung diseases to further progress treatment and therapy.